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butabarbital will reduce the extent or influence of amlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.butabarbital will reduce the level or impact of fosphenytoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Watch.butabarbital will lessen the extent or influence of cannabidiol by impacting hepat